The massacre at Vassy exacerbated religious tensions that had been simmering for years, serving as a rallying cry for both Catholics and Protestants, each side seeing the incident as justification for their cause. Within just a few weeks of the massacre, violence erupted across the country.

On the 22nd March 1621, Dutch legal scholar Hugo Grotius – also known as Hugo de Groot – escaped imprisonment in Loevestein Castle concealed inside a book chest.